Notch Secretory Specification
Gene co-expression module in Goblet cells
| Category | Epithelial development |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
SPIB is a transcription factor marking BEST4+ colonocytes and tuft/secretory progenitor cells. HES4 and HES5 are Notch target genes (neighbor M64 has HES1/NRARP, confirming Notch neighborhood). NOTCH2 is the Notch receptor critical for secretory cell specification in the colon. RHOV (Rho GTPase) and SIPA1L2 regulate cytoskeletal dynamics. EREG (epiregulin) and PDGFA are growth factors; EDN1 (endothelin-1) is a vasoactive/mitogenic peptide; MYC drives proliferation. THBS1 modulates ECM interactions. Strongest inflammation-downregulation in batch (UC: -1.335, CD: -1.063), large remission recovery. This module reflects a Notch-dependent secretory progenitor specification state with associated growth factor signaling, lost during active IBD.
Genes
EDN1, EREG, FKBP1A, GPRC5C, HES4, HES5, MYC, NOTCH2, PDGFA, RHOV, SIPA1L2, SPIB, THBS1
Most correlated modules
- Notch Target Response · correlation 0.74
- Mature Colonocyte Function · correlation 0.71
- Colonocyte Differentiation Program · correlation 0.61
- BMP Signaling Response · correlation 0.57
- Co-translational Chaperone · correlation 0.54
- Goblet Cell Differentiation · correlation 0.51
- Immediate Early Gene · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.