KLF10 — KLF transcription factor 10

KLF10 belongs to a gene co-expression module in 15 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

KLF10's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	ATF4 Stress Response Stress	ATF4, BRD2, CCNYL1, ERO1B, FUS, GLA, HMGCS1, INSIG1 +3 more	View in SCUBA
CD4⁺ T cells	Metabolic reprogramming Housekeeping	ATG16L2, ATP1A1, CCNYL1, CSKMT, EIF1AY, FAM241A, HMGCS1, ING1 +12 more	View in SCUBA
Endothelial	NF-κB Early Response Inflammation	BCL3, BHLHE40, ICAM1, INSIG1, ITPKC, LDLR, MYADM, RND1 +3 more	View in SCUBA
Fibroblasts	NF-κB Epigenetic Reprogramming Inflammatory	BCL3, BTG2, CDKN1A, CSRNP1, DUSP5, EGR2, KDM6B, LDLR +3 more	View in SCUBA
Gamma-delta T cells	TGF-beta Response Immune regulation	ADGRE5, CD83, CHMP1B, CHST7, DDIT3, DNAAF2, EHD4, FAM43A +15 more
Goblet cells	Notch Target Response Epithelial development	BRI3, CLDN3, GDF15, HES1, ID1, NRARP, TRAF4	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more	View in SCUBA
Lymphatic endothelial	Lymphatic Valve Formation Valve formation	CCN1, CCN2, DUSP2, FOXC1, GADD45B, GADD45G, GATA2, HES5 +9 more	View in SCUBA
Macrophages	NF-κB Inflammatory Activation Inflammatory	ADM, CCL2, CCL20, CCL7, CLEC4E, CXCL1, CXCL2, CXCL3 +19 more	View in SCUBA
Monocytes	Integrated Stress Response Stress	CDKN1A, CSRNP1, EIF2AK3, HBEGF, MAFF, PIM3, TIPARP	View in SCUBA
Mucosal-associated invariant T cell	Stress-Induced Growth Arrest Stress	CDKN1A, GNA15, KDM6B, MMP9, MYADM, NOCT, NR4A3, PLK3 +8 more
Natural Killer cells	Autophagy-Inflammation Stress Stress	BCL2A1, DDIT3, ICAM1, IFFO2, JMJD6, MAP1LC3B, MKNK2, SIK3 +3 more	View in SCUBA
Neutrophils	CC Chemokine Secretion Cytokine & chemokine secretion	C15orf48, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, CCRL2, CD83 +4 more
Pericytes	NF-κB Inflammatory Response Inflammatory	ABL2, ADAMTS9, ARL4A, BCL3, BHLHE40, FOSL2, ICAM1, PIM3 +3 more	View in SCUBA
Smooth muscle cells	BMP/TGF-beta response Activation	APBB2, GLS, ID1, ID2, IRS2, RND3, SEC11C, SIPA1L2 +1 more	View in SCUBA

About the gene

Synonyms	EGRA, TIEG, TIEG1
Chromosome	8: 102648784-102655725
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding, Repressor
Biological process	Biological rhythms, Transcription, Transcription regulation

Function

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.