CLDN3 — Claudin 3
CLDN3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLDN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Surface colonocyte differentiation Epithelial development | AGR3, ATP1B1, BMP3, DSP, KLF5, KRT20, NEURL1B, PDLIM1 +2 more | View in SCUBA |
| Goblet cells | Notch Target Response Epithelial development | BRI3, GDF15, HES1, ID1, KLF10, NRARP, TRAF4 | View in SCUBA |
About the gene
| Synonyms | C7orf1, CPE-R2, CPETR2, HRVP1, RVP1 |
|---|---|
| Chromosome | 7: 73768997-73770270 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
Function
Barrier-forming claudin. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.