TRAF4 — TNF receptor associated factor 4
TRAF4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRAF4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB activation TCR/AP1/NFKb pathway | ABCF1, BCL2A1, BUD23, BZW2, CALR, CEBPZ, DDX21, DENND4A +21 more | View in SCUBA |
| Gamma-delta T cells | NF-κB Activation Inflammation | DUSP5, GADD45A, HERPUD1, IL21R, KDM6B, MAFF, NAMPT, NFKB1 +13 more | |
| Goblet cells | Notch Target Response Epithelial development | BRI3, CLDN3, GDF15, HES1, ID1, KLF10, NRARP | View in SCUBA |
| Innate lymphoid cells | ILC Survival Residency Gut residency | ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4 +25 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Activation Inflammation | DUSP5, DUSP8, ELL2, GABARAPL1, IRF2BP2, MAFF, NAMPT, NFKB1 +8 more |
About the gene
| Synonyms | CART1, MLN62, RNF83 |
|---|---|
| Chromosome | 17: 28744011-28750956 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Developmental protein, Transferase |
| Biological process | Apoptosis, Immunity, Innate immunity, Ubl conjugation pathway |
Function
Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.