mRNA Stability Control
Gene co-expression module in Goblet cells
| Category | RNA processing & translation |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
ZFP36L1 is a zinc-finger ARE-binding protein that promotes mRNA degradation. PNRC1 links nuclear receptors to mRNA decapping/decay. BTG1 is an anti-proliferative gene promoting differentiation and cell quiescence, also involved in mRNA deadenylation via CAF1. TENT5C (FAM46C) is a non-canonical poly-A polymerase expressed in secretory cells including goblet cells. TXNIP is a stress-responsive metabolic sensor. SRSF5 is a splicing factor. DNAJB6 is a chaperone. TSC22D1 is a TGF-beta-inducible transcription factor. Dominant theme: mRNA stability control and quiescence/differentiation. Significantly reduced during UC inflammation and restored in remission.
Genes
BTG1, DNAJB6, PNRC1, SRSF5, TENT5C, TSC22D1, TUBA1A, TXNIP, UBXN1, YPEL5, ZBTB20, ZFP36L1, ZNF292, ZNF91
Most correlated modules
- BMP Signaling Response · correlation 0.73
- Nuclear Architecture · correlation 0.73
- Chromatin Remodeling · correlation 0.68
- Progenitor Identity Program · correlation 0.68
- RNA Decay Processing · correlation 0.62
- Notch Target Response · correlation 0.56
- Goblet Cell Identity · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.