SMC3 — Structural maintenance of chromosomes 3
SMC3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cellular biosynthesis Housekeeping | CCDC32, CTSB, HDGF, MEA1, MESD, MFSD6, MRPS11, MTHFD2 +9 more | View in SCUBA |
| CD8⁺ T cells | Epigenetic Chromatin Maintenance DNA/chromatin regulation | BAZ1B, DDX46, DNMT1, HNRNPAB, NASP, NOP56, SET, SMC1A +2 more | View in SCUBA |
| Endothelial | DNA Damage Repair DNA/chromatin regulation | APPL1, GPAA1, HMGB1, HNRNPM, HNRNPR, NAP1L4, NCL, PRDX3 +7 more | View in SCUBA |
| Gamma-delta T cells | Mitotic Spindle Cell cycle | CAPRIN1, CDK5RAP2, CKAP5, CNTRL, DEK, DNMT1, FAM111A, GMPS +11 more | |
| Goblet cells | Chromatin Remodeling Repair chromatin regulation & transcription | CBX5, HACD3, NAP1L1, PARP1, PPM1G, PRKDC, PSIP1, SMC1A +1 more | View in SCUBA |
| Innate lymphoid cells | NK Cytotoxic Regulation Cytotoxicity | ARHGAP30, BIN2, CAPN12, CHD9, CLK1, CTSC, CYB5B, DDX27 +29 more | View in SCUBA |
| Macrophages | Replication Chromatin Assembly Cell cycle | ANP32B, CBX3, CDK4, COPS3, DEK, DNMT1, EMC8, EXOSC8 +22 more | View in SCUBA |
About the gene
| Synonyms | BAM, bamacan, CSPG6, HCAP, SMC3L1 |
|---|---|
| Chromosome | 10: 110567684-110606048 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, DNA damage, DNA repair, Meiosis, Mitosis |
Function
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.