HACD3 — 3-hydroxyacyl-CoA dehydratase 3
HACD3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HACD3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Proteasomal Degradation Protein processing & ER | GNL3, MRPL36, NME4, NUDT5, PON2, PSMA1, PSMB5, PSMC1 +3 more | View in SCUBA |
| Goblet cells | Chromatin Remodeling Repair chromatin regulation & transcription | CBX5, NAP1L1, PARP1, PPM1G, PRKDC, PSIP1, SMC1A, SMC3 +1 more | View in SCUBA |
| Macrophages | DNA Replication Metabolism Cell cycle | AGPAT5, CBX1, DCK, FADS1, HADH, ICMT, IDH2, MTHFD1 +11 more | View in SCUBA |
About the gene
| Synonyms | B-ind1, HSPC121, PTPLAD1 |
|---|---|
| Chromosome | 15: 65530418-65578349 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Lyase |
| Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Function
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.