S-phase DNA Replication
Gene co-expression module in Goblet cells
| Category | Cell cycle |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
All top hub genes are canonical S-phase/DNA replication markers: PCLAF (PCNA-clamp loader associated factor, S-phase marker), DHFR (dTMP synthesis), TK1 (thymidine kinase, S-phase), ASF1B (histone chaperone, S-phase), FEN1 (Okazaki fragment processing), TYMS (thymidylate synthase), BRCA1 (DNA repair/replication), MYBL2 (G2/M transcription factor), CDC6 (replication licensing). Low mean expression (0.152) and 22.6% detection indicate a subset of actively cycling cells. Module coherence is core. Together with neighbor M51 and M80 which also contain replication genes, this is clearly an S-phase DNA replication program.
Genes
ASF1B, BRCA1, CDC6, CENPU, DHFR, FEN1, MYBL2, PCLAF, TK1, TYMS
Most correlated modules
- Replication Fork Checkpoint · correlation 0.95
- MCM Replication Licensing · correlation 0.88
- FOXM1-driven G2/M · correlation 0.86
- Chromatin Remodeling Repair · correlation 0.79
- Spliceosome Assembly · correlation 0.77
- S/G2 Preparation · correlation 0.73
- Mitochondrial Chaperone · correlation 0.72
- Pyroptosis Stress Response · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.