KCTD12 — Potassium channel tetramerization domain containing 12

KCTD12 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

KCTD12's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Hypoxia metabolic stress Stress	ARG2, ARL4D, AXIN2, BNIP3, CITED4, CNKSR2, GCA, GSTM3 +13 more	View in SCUBA
Endothelial	Quiescent EC Identity Endothelial cell development	ADRB1, CAMK2D, CLU, CYP1B1, FAM20A, FOXP1, FZD6, GCHFR +19 more	View in SCUBA
Glial cells	ECM Homeostatic Regulation ECM remodeling	BPTF, MAPRE2, OAF, SASH1, ST3GAL6, TIMP2, TTC3	View in SCUBA
Goblet cells	Goblet Cell Identity Epithelial development	CELF2, FOXP1, FRYL, GPRIN3, HOXB13, ITPR2, NEDD4L, NFAT5 +5 more	View in SCUBA
Lymphatic endothelial	Lymphatic Vascular Stability endothelial development	GJA1, GLT8D2, HIC1, HSD17B12, IGFBP4, MAF, ROBO4, S1PR1 +6 more	View in SCUBA
Macrophages	Myeloid Innate Signaling Innate immunity	ADCY7, ARHGAP18, BMP2K, C3AR1, C6orf62, CD46, CD84, CLTC +34 more	View in SCUBA
Monocytes	Macrophage Innate Activation Innate immunity	DMXL2, FGL2, HSD17B4, MPEG1, PTPRC, SAMHD1, TLR4, VPS35 +1 more	View in SCUBA
Pericytes	Arterial Pericyte Identity Developmental	ATP13A3, BMX, FBLN2, GJA5, LTC4S, PLLP, SEMA3G, TMEM100 +1 more	View in SCUBA

About the gene

Synonyms	C13orf2, KIAA1778, PFET1
Chromosome	13: 76880175-76886405
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins

Function

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.