Mitochondrial OxPhos
Gene co-expression module in Goblet cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
CYC1 encodes cytochrome c1, a core subunit of Complex III (ubiquinol-cytochrome c reductase); NDUFV1 is a Complex I subunit; PFKL is phosphofructokinase-L (glycolysis); TECR is involved in fatty acid elongation in ER; PXMP2 is a peroxisomal membrane protein; PPP1R1B (DARPP-32) and MAZ are signaling/transcription factors. The module is dominated by mitochondrial electron transport chain components (CYC1, NDUFV1) and metabolic enzymes. Decrease during UC inflammation and recovery in remission mirrors M55 and M54 neighbors, supporting a shared mitochondrial/metabolic housekeeping program. NAA38 (NatA acetyltransferase subunit) is a general housekeeping gene. The neighborhood context strongly supports OxPhos/mitochondrial metabolism.
Genes
CYC1, MAZ, NAA38, NDUFV1, PFKL, PPP1R1B, PXMP2, TECR
Most correlated modules
- Electron Transport Chain · correlation 0.78
- Mitochondrial Biogenesis · correlation 0.77
- Mitochondrial OxPhos · correlation 0.73
- Glutathione Detoxification · correlation 0.70
- Mitochondrial Chaperone · correlation 0.66
- Mitochondrial Metabolism · correlation 0.66
- Anti-inflammatory Lipid Signaling · correlation 0.63
- S-phase DNA Replication · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.