TECR — Trans-2,3-enoyl-CoA reductase
TECR belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TECR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | DNA Replication Cell cycle | CENPX, DNMT1, ICMT, IDH2, MCM3, MCM4, MCM5, MCM6 +11 more | View in SCUBA |
| Goblet cells | Mitochondrial OxPhos Mitochondrial & OxPhos | CYC1, MAZ, NAA38, NDUFV1, PFKL, PPP1R1B, PXMP2 | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Metabolic Housekeeping Mitochondrial & OxPhos | ALKBH7, ATF6B, BCAS1, COQ8A, DDT, DNAJC4, DPM3, EIF3M +16 more | View in SCUBA |
| Macrophages | Retromer Endosomal Sorting Vesicular traficking | ABHD15, ARHGAP45, ARHGAP9, CNPY3, CRBN, CTSO, DAB2, DRAM2 +20 more | View in SCUBA |
About the gene
| Synonyms | GPSN2, MRT14, SC2, TER |
|---|---|
| Chromosome | 19: 14517085-14565980 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism |
Function
Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway. Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl- CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.