Heat Shock Response
Gene co-expression module in Goblet cells
| Category | Stress |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Module is dominated by cytosolic heat shock proteins and chaperones: HSP90 (HSP90AA1, HSP90AB1), HSP70 family (HSPA1A, HSPA1B, HSPA8, HSPH1), co-chaperones (DNAJA1, HSPB1). This is a canonical proteotoxic/heat shock stress response. The negative correlation with UC inflammation and positive association with remission suggests this reflects a physiological stress-buffering program in healthy goblet cells rather than purely a dissociation artifact. Peripheral genes (WEE1, EIF5, EIF1AX) likely co-regulated under stress.
Genes
DNAJA1, EIF1AX, EIF5, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8, HSPB1, HSPH1, MRPL18, SLC20A1, WEE1, ZNF207
Most correlated modules
- Immediate Early Gene · correlation 0.62
- NF-κB Stress Response · correlation 0.61
- Stress Chromatin Remodeling · correlation 0.56
- Goblet Cell Differentiation · correlation 0.47
- Mitotic Spindle Assembly · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.