Mitotic Spindle Assembly
Gene co-expression module in Goblet cells
| Category | Cell cycle |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 14 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes: AURKA (Aurora kinase A, mitotic entry/spindle), CENPA (centromere histone, kinetochore assembly), ARHGAP11A (RhoGAP, mitotic spindle positioning), CKS2 (CDK subunit, mitotic progression), KIF14 (kinesin, cytokinesis), KNSTRN (kinetochore), TTK (spindle assembly checkpoint kinase), KPNA2 (importin, mitotic regulation), FAM83D (spindle), PLK1 (polo-like kinase 1, master mitotic kinase), CDKN3 (CDK phosphatase), KNL1 (kinetochore scaffold), CKAP5 (XMAP215, microtubule polymerase), UBE2S (APC/C ubiquitin ligase). All genes core membership. This is a tightly defined mitotic spindle assembly checkpoint and kinetochore module, centered on PLK1/AURKA/TTK signaling. Distinguishable from M25 (spindle midzone/cytokinesis) and M62 (proliferation markers) by focus on spindle assembly checkpoint.
Genes
ARHGAP11A, AURKA, CDKN3, CENPA, CKAP5, CKS2, FAM83D, KIF14, KNL1, KNSTRN, KPNA2, PLK1, TTK, UBE2S
Most correlated modules
- Mitotic Proliferation · correlation 0.97
- Chromosome Segregation · correlation 0.96
- G2/M Cyclin Program · correlation 0.96
- S/G2 Preparation · correlation 0.85
- FOXM1-driven G2/M · correlation 0.76
- Basal Transcription · correlation 0.66
- Chromatin Organization · correlation 0.65
- Heat Shock Response · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.