Actin Cytoskeleton Organization
Gene co-expression module in Macrophages
| Category | Cytoskeletal |
|---|---|
| Genes | 29 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 29 genes have a known function matching the annotation |
Why this annotation
Hub genes strongly implicate cytoskeletal organization: TPM3 (tropomyosin-3, actin filament stabilization), SEPTIN7 (septin cytoskeleton), MAPRE1 (EB1, microtubule plus-end tracking), ARHGDIA (Rho GDP dissociation inhibitor, regulates Rho GTPases), WDR1 (AIP1, promotes cofilin-mediated actin disassembly), CDC42 (Rho GTPase, actin polymerization/filopodia), ACTR3 (Arp3, Arp2/3 complex actin branching), ARF1 (vesicular/cytoskeletal). MOB1A (Hippo pathway, also involved in cytoskeletal regulation), MORF4L1 (chromatin). RNA-binding genes (PCBP1, HNRNPK, EIF4G2) are present but secondary. The cytoskeletal theme is dominant and consistent with macrophage motility/morphology programs. In the context of neighboring M29 (which also contains ACTR2, SEPTIN2), this module represents the actin/cytoskeletal organization program.
Genes
ACTR3, ARF1, ARHGDIA, ARPC4, CDC42, DERL1, EIF4G2, GARS1, HNRNPK, MACROH2A1, MAPRE1, MOB1A, MORF4L1, PCBP1, PPP1R18, PPP2CA, PSMC6, SAR1A, SAR1B, SEPTIN7, SPCS3, SRP72, SSR3, TPM3, TUBGCP2, WDR1, YIPF6, YWHAE, ZYX
Most correlated modules
- ER Protein Processing · correlation 0.97
- Autophagy Lysosomal Regulation · correlation 0.96
- Protein Biogenesis · correlation 0.96
- Phagocytic Endolysosomal · correlation 0.96
- Glycogen Metabolism · correlation 0.95
- ER Membrane Homeostasis · correlation 0.95
- RNA Processing & Repair · correlation 0.94
- Nuclear Pore Transport · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.