RNA Processing & Repair
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 40 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 15 of 40 genes have a known function matching the annotation |
Why this annotation
Hub genes XRCC5/XRCC6 (Ku70/Ku80 heterodimer, DNA end-joining repair) anchor this module. Supporting genes include aminoacyl-tRNA synthetases (EPRS1, NARS1), heterogeneous nuclear ribonucleoproteins (HNRNPF, HNRNPR, HNRNPM), chaperonin complex subunits (CCT4, CCT6A), nucleolin (NCL), and translation factor EIF5B. All genes have weak membership and uniform expression, consistent with constitutive housekeeping activity. Mild prolif_mac enrichment for SET and HNRNPR is consistent with higher transcriptional demand in proliferating cells. The module combines RNA processing and DNA maintenance — core housekeeping functions.
Genes
BRD7, CCDC59, CCT4, CCT6A, CNDP2, EIF3J, EIF5B, EMC4, EPRS1, FRG1, HADHA, HNRNPF, HNRNPM, HNRNPR, LSM12, MAZ, METAP2, MMADHC, MPLKIP, NARS1, NCL, NDUFS2, PTGES3, PUF60, RBMX2, RPAIN, RTF1, SCAMP3, SERBP1, SET, SF3B2, SRRM1, TFAM, TRIM28, UQCRC2, VPS4A, WAS, XRCC5, XRCC6, ZC3H15
Most correlated modules
- Protein Biogenesis · correlation 0.98
- Ribosome Biogenesis · correlation 0.96
- mRNA Splicing Processing · correlation 0.95
- Actin Cytoskeleton Organization · correlation 0.94
- Nuclear Pore Transport · correlation 0.94
- Ubiquitin-Proteasome System · correlation 0.94
- ER Protein Processing · correlation 0.93
- Replication Chromatin Assembly · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.