Mitotic Chromosome Condensation
Gene co-expression module in Macrophages
| Category | Cell cycle |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 13 genes have a known function matching the annotation |
Why this annotation
SMC4 and NCAPD2 are condensin complex subunits required for mitotic chromosome condensation. KIF22 is a kinesin motor for chromosome alignment. TACC3 is a centrosome/spindle pole protein. RACGAP1 is essential for cytokinesis. CKS1B is a CDK1 regulatory subunit active in mitosis. H2AX and H4C3 are histones enriched during mitosis. HMGB2 is a chromatin architectural protein highly expressed in proliferating cells. SKA2 and DTYMK support kinetochore function and nucleotide metabolism. TMPO (LAP2) is a nuclear lamina protein involved in mitotic nuclear envelope breakdown. This is a tight mitotic chromosome condensation/segregation module with very high prolif_mac enrichment.
Genes
CKS1B, DTYMK, H2AX, H4C3, HMGB2, KIF22, NCAPD2, RACGAP1, SAC3D1, SKA2, SMC4, TACC3, TMPO
Most correlated modules
- Mitotic Spindle · correlation 0.94
- S-phase DNA Replication · correlation 0.91
- Mitotic Spindle Assembly · correlation 0.87
- Centrosome & DNA Repair · correlation 0.82
- DNA Replication Metabolism · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.