SMC4 — Structural maintenance of chromosomes 4
SMC4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMC4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitotic Spindle Cell cycle | CENPF, GTSE1, HMMR, KIF11, KIF22, KIFC1, NCAPG, SGO1 +3 more | View in SCUBA |
| CD4⁺ T cells | RNA & Chromatin Regulation RNA processing | ATRX, DCP2, DIP2A, HNRNPLL, KDM5B, NCOR1, OGDH, RIOK3 +7 more | View in SCUBA |
| Endothelial | Mitotic Cell Cycle Cell cycle | ANP32E, BIRC5, CENPN, CENPW, CKS1B, DTYMK, GGH, PRR11 +3 more | View in SCUBA |
| Macrophages | Mitotic Chromosome Condensation Cell cycle | CKS1B, DTYMK, H2AX, H4C3, HMGB2, KIF22, NCAPD2, RACGAP1 +4 more | View in SCUBA |
| Neutrophils | S-G2-M Cell Cycle Cell cycle | ATAD2, CENPP, CNTRL, EZH2, LNPEP, MIS18BP1, RRM2, TOPBP1 +1 more |
About the gene
| Synonyms | CAP-C, hCAP-C, SMC4L1 |
|---|---|
| Chromosome | 3: 160399274-160434954 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, DNA condensation, Mitosis |
Function
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.