KIF22 — Kinesin family member 22
KIF22 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KIF22's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitotic Spindle Cell cycle | CENPF, GTSE1, HMMR, KIF11, KIFC1, NCAPG, SGO1, SHCBP1 +3 more | View in SCUBA |
| CD8⁺ T cells | CDK1-Aurora Kinase Mitosis Cell cycle | AURKB, BIRC5, CCNA2, CDK1, CDKN3, CKS1B, KIFC1, MAD2L1 +2 more | View in SCUBA |
| Macrophages | Mitotic Chromosome Condensation Cell cycle | CKS1B, DTYMK, H2AX, H4C3, HMGB2, NCAPD2, RACGAP1, SAC3D1 +4 more | View in SCUBA |
| Natural Killer cells | Mitotic Spindle Cell cycle | ARL6IP1, ASPM, CENPF, CKS1B, MKI67, NUSAP1, PTTG1, TACC3 +3 more | View in SCUBA |
About the gene
| Synonyms | Kid, KNSL4, OBP-1, OBP-2 |
|---|---|
| Chromosome | 16: 29790727-29805385 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding, Motor protein |
Function
Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.