H2AX — H2A.X variant histone
H2AX belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
H2AX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Anabolic Activation Response Housekeeping | ABHD5, ATF4, ATP6V0C, ATP6V1G1, BCL7B, BUD31, CALM2, CHRAC1 +26 more | |
| Lymphatic endothelial | DNA Damage Response DNA/chromatin regulation | BRD2, BTG2, CITED2, HBEGF, HEXIM1, INTS6, MAFB, NR4A1 +7 more | View in SCUBA |
| Macrophages | Mitotic Chromosome Condensation Cell cycle | CKS1B, DTYMK, H4C3, HMGB2, KIF22, NCAPD2, RACGAP1, SAC3D1 +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | AP-1 Immediate Early Stress | AMD1, BRD2, CITED2, CSKMT, FUS, GADD45B, GADD45G, HEXIM1 +17 more | |
| Natural Killer cells | Histone Variant Remodeling DNA regulation & transcription | ARF5, C17orf49, DDOST, GNB2, H2AZ1, H2AZ2, IFT25, MACROH2A1 +2 more | View in SCUBA |
About the gene
| Synonyms | H2AFX |
|---|---|
| Chromosome | 11: 119093874-119095465 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Cell cycle, DNA damage, DNA recombination, DNA repair, Host-virus interaction, Meiosis |
Function
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.