DTYMK — Deoxythymidylate kinase
DTYMK belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DTYMK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Cell Cycle Proliferation Cell cycle | ALYREF, ANP32E, BCL2L12, BIRC5, BUB3, CENPW, CEP55, CKS1B +4 more | View in SCUBA |
| CD8⁺ T cells | Mitotic Spindle Cell cycle | ASF1B, CENPN, DDX39A, GGH, HMGB2, HMGN2, LMNB1, STMN1 +3 more | View in SCUBA |
| Endothelial | Mitotic Cell Cycle Cell cycle | ANP32E, BIRC5, CENPN, CENPW, CKS1B, GGH, PRR11, PTTG1 +3 more | View in SCUBA |
| Goblet cells | S/G2 Preparation Cell cycle | EXOSC8, HMGN2, LMNB1, LSM3, LSM5, MIS18A, MIS18BP1, SMC2 +4 more | View in SCUBA |
| Macrophages | Mitotic Chromosome Condensation Cell cycle | CKS1B, H2AX, H4C3, HMGB2, KIF22, NCAPD2, RACGAP1, SAC3D1 +4 more | View in SCUBA |
About the gene
| Synonyms | CDC8, TMPK, TYMK |
|---|---|
| Chromosome | 2: 241675747-241686944 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Nucleotide biosynthesis |
Function
Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.