CKS1B — CDC28 protein kinase regulatory subunit 1B
CKS1B belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CKS1B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Cell Cycle Proliferation Cell cycle | ALYREF, ANP32E, BCL2L12, BIRC5, BUB3, CENPW, CEP55, DTYMK +4 more | View in SCUBA |
| CD8⁺ T cells | CDK1-Aurora Kinase Mitosis Cell cycle | AURKB, BIRC5, CCNA2, CDK1, CDKN3, KIF22, KIFC1, MAD2L1 +2 more | View in SCUBA |
| Endothelial | Mitotic Cell Cycle Cell cycle | ANP32E, BIRC5, CENPN, CENPW, DTYMK, GGH, PRR11, PTTG1 +3 more | View in SCUBA |
| Gamma-delta T cells | Mitosis Execution Cell cycle | ASF1B, BUB1, CDCA8, CENPE, CENPF, EZH2, MAD2L1, MKI67 +12 more | |
| Hematopoietic progenitor cells | Mitotic Spindle Checkpoint Cell cycle | CENPF, CENPW, GGH, HMGB2, MAD2L1, PTTG1, UBE2T, ZWINT | |
| Macrophages | Mitotic Chromosome Condensation Cell cycle | DTYMK, H2AX, H4C3, HMGB2, KIF22, NCAPD2, RACGAP1, SAC3D1 +4 more | View in SCUBA |
| Natural Killer cells | Mitotic Spindle Cell cycle | ARL6IP1, ASPM, CENPF, KIF22, MKI67, NUSAP1, PTTG1, TACC3 +3 more | View in SCUBA |
About the gene
| Synonyms | CKS1, ckshs1 |
|---|---|
| Chromosome | 1: 154974653-154979251 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division |
Function
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.