SCUBA

TMPO — Thymopoietin

TMPO belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TMPO's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsMitotic Spindle
Cell cycle
CENPF, GTSE1, HMMR, KIF11, KIF22, KIFC1, NCAPG, SGO1 +3 moreView in SCUBA
CD4⁺ T cellsEpigenetic regulation
DNA/chromatin regulation
AFF4, ARID1B, CTSA, DGKH, FUBP1, JARID2, PDCD6, SYNCRIP +6 moreView in SCUBA
CD8⁺ T cellsS-phase Chromatin Replication
Cell cycle
ANP32E, BRCA2, CKAP2, HDGF, HP1BP3, LBR, MIS18BP1, NSD2 +4 moreView in SCUBA
EndothelialMitotic Cell Cycle
Cell cycle
ANP32E, BIRC5, CENPN, CENPW, CKS1B, DTYMK, GGH, PRR11 +3 moreView in SCUBA
Gamma-delta T cellsMitotic Spindle
Cell cycle
CAPRIN1, CDK5RAP2, CKAP5, CNTRL, DEK, DNMT1, FAM111A, GMPS +11 more
Goblet cellsS/G2 Preparation
Cell cycle
DTYMK, EXOSC8, HMGN2, LMNB1, LSM3, LSM5, MIS18A, MIS18BP1 +4 moreView in SCUBA
Hematopoietic progenitor cellsS-phase Progression
Cell cycle
ATAD2, ATAD5, BRCA2, DNMT1, FANCI, LMNB1, RRM1, SMC2 +1 more
MacrophagesMitotic Chromosome Condensation
Cell cycle
CKS1B, DTYMK, H2AX, H4C3, HMGB2, KIF22, NCAPD2, RACGAP1 +4 moreView in SCUBA
MonocytesCCR2+ Monocyte Identity
Innate immunity
CCR2, GAPT, LYST, MAP3K1, MNDA, POU2F2, RGS18, SLC24A4 +4 moreView in SCUBA
Mucosal-associated invariant T cellSWI/SNF Chromatin Remodeling
DNA/chromatin regulation
ARCN1, ATL3, CASP8, CYFIP2, DENND4C, DIDO1, DPP4, ERAP1 +8 more
Natural Killer cellsG2/M Transition
Cell cycle
ANP32B, CARHSP1, NSD2, PHF19, SMC2, STMN1, TUBA1B, TUBBView in SCUBA

About the gene

SynonymsLAP2, LEMD4, TP
Chromosome12: 98515579-98550351
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classHuman disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Molecular functionDNA-binding

Function

May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1. TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.