SKA2 — Spindle and kinetochore associated complex subunit 2
SKA2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SKA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Remodeling DNA/chromatin regulation | ANP32B, ATP5IF1, CALM3, CBX3, COMMD4, HAT1, HMGA1, HMGB1 +9 more | View in SCUBA |
| CD4⁺ T cells | Effector Immune Activation Immune regulation | ABI3, APBB1IP, ASB2, BUB3, CALCOCO2, CASP4, COMMD7, CTSD +7 more | View in SCUBA |
| Gamma-delta T cells | Mitotic Spindle Cell cycle | CAPRIN1, CDK5RAP2, CKAP5, CNTRL, DEK, DNMT1, FAM111A, GMPS +11 more | |
| Macrophages | Mitotic Chromosome Condensation Cell cycle | CKS1B, DTYMK, H2AX, H4C3, HMGB2, KIF22, NCAPD2, RACGAP1 +4 more | View in SCUBA |
About the gene
| Synonyms | FAM33A, FLJ12758 |
|---|---|
| Chromosome | 17: 59109857-59155260 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization- coupled manner. In the complex, it is required for SKA1 localization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.