RNA Splicing Regulation
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 22 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
This module has unknown coherence with all genes showing weak membership, suggesting a poorly defined background module. The top hub genes include splicing factors (SNW1, CDC5L, SMU1, NSRP1, THRAP3), general transcriptional regulators (CEBPZ, SAP30BP), a chaperone (DNAJC7), and housekeeping components. Expression is largely uniform across subsets with no strong cell-state specificity. The module likely reflects co-expression noise among broadly expressed housekeeping genes involved in RNA processing and general nuclear functions rather than a coherent biological program.
Genes
ABCF1, CDC42SE1, CDC5L, CDV3, CEBPZ, DNAJC7, DYNC1LI1, FGFR1OP2, GNL3, GORASP2, NSRP1, PPP1R2, SAP30BP, SMNDC1, SMU1, SNW1, TDG, THRAP3, TMED5, UBXN4, UFM1, ZCCHC10
Most correlated modules
- RNA Processing Regulation · correlation 0.98
- RAS-MAPK Signaling · correlation 0.97
- mRNA Splicing Processing · correlation 0.96
- Protein Biogenesis · correlation 0.95
- Ubiquitin-ERAD Proteostasis · correlation 0.95
- Ubiquitin-Proteasome System · correlation 0.95
- Golgi-Endosome Trafficking · correlation 0.94
- Transcriptional Elongation · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.