ER Membrane Homeostasis
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 27 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes include RTN3/RTN4 (ER-shaping reticulons), CANX (calnexin, ER chaperone), TMEM33 (ER membrane protein), PTDSS1 (phosphatidylserine synthase, ER-localized), CAPZA1 (actin capping), and SCARB2 (lysosomal membrane). The module is dominated by ER membrane-resident and membrane-shaping proteins. MAGT1 is a magnesium transporter in the ER membrane. SLC31A1 is a copper transporter. While mixed, the strongest theme is ER membrane organization and lipid/membrane homeostasis. All genes show weak membership and the module has unknown coherence, suggesting a loosely co-expressed housekeeping program in mono_mac cells.
Genes
ATP6V1A, BNIP2, CANX, CAPZA1, CD164, CMTM6, COPB1, EXOC5, GFM1, IQGAP1, MAGT1, MYH9, PAPOLA, PLEKHB2, PTDSS1, RAD23B, RTN3, RTN4, SCARB2, SERINC3, SLC31A1, SRGN, TM9SF3, TMEM33, TTYH3, YWHAG, ZDHHC5
Most correlated modules
- Autophagy Vesicular Trafficking · correlation 0.98
- Ubiquitin-ERAD Proteostasis · correlation 0.97
- RNA Processing Regulation · correlation 0.96
- mRNA Splicing Processing · correlation 0.96
- Macrophage Endocytic Signaling · correlation 0.96
- ER Protein Quality Control · correlation 0.95
- Endolysosomal Trafficking · correlation 0.95
- ER-Golgi Trafficking · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.