HMGB3 — High mobility group box 3
HMGB3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HMGB3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | G2/M Mitosis Cell cycle | AURKA, BUB1, CCDC34, CCNB1, CCNB2, CDC20, CDKN3, CENPA +7 more | View in SCUBA |
| Goblet cells | Chromatin Organization chromatin regulation & transcription | CBX3, HMGB1, HMGN1, HNRNPA2B1, PTMA, STMN1, TPRKB | View in SCUBA |
| Macrophages | MMP-driven ECM Remodeling ECM remodeling | A4GALT, ACP5, ASB2, ASMTL, ATP6V0D2, BID, CFP, CPOX +12 more | View in SCUBA |
About the gene
| Synonyms | HMG2A, HMG4, MGC90319 |
|---|---|
| Chromosome | X: 150980509-150990771 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Immunity, Innate immunity, Transcription, Transcription regulation |
Function
Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.