NPC2 — NPC intracellular cholesterol transporter 2
NPC2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NPC2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venular Inflammatory Activation Inflammation | ACKR1, AIM2, ARL4C, ASAP3, BNC2, CFP, DUSP23, FAM3D +8 more | View in SCUBA |
| Fibroblasts | Complement-secreting Fibroblast Immune interaction | ADI1, ARL6IP5, C1R, C2, CYB5A, FCGRT, FTH1, FTL +9 more | View in SCUBA |
| Glial cells | Oxidative Stress Response Stress | CAP1, CD59, CXXC5, EEF2, ENO1, HNRNPF, KLF9, NDUFA11 +3 more | View in SCUBA |
| Lymphatic endothelial | Integrin Focal Adhesion migration & adhesion | APLP2, ATP5F1A, ATP5PB, DEK, ITGB1, LIMS1, MCFD2, NUCKS1 +4 more | View in SCUBA |
| Macrophages | MHC-II Antigen Presentation Innate immunity | AIF1, B2M, C1QA, C1QB, C1QC, CD68, CD74, CST3 +19 more | View in SCUBA |
| Monocytes | Monocyte Lipid Handling Lysosomal & pahgocytosis | AKR1A1, CD81, FUOM, ISOC2, LAIR1, RGL1, SIGLEC1, SPATS2L +1 more | View in SCUBA |
| Smooth muscle cells | Translocon & Proteostasis Housekeeping | ATP6V0E1, CLTA, EIF3F, NOP10, PSMA1, SEC61G, ST13, SUB1 +2 more | View in SCUBA |
About the gene
| Synonyms | EDDM1, HE1, NP-C2 |
|---|---|
| Chromosome | 14: 74476192-74494177 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins, Transporters |
| Biological process | Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport |
Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.