Non-classical Monocyte
Gene co-expression module in Monocytes
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include RNASET2 (lysosomal RNase), NAAA (lysosomal lipid amidase), SIDT2 (lysosomal RNA transporter), FCGR3A (CD16, non-classical monocyte marker), CD300A (inhibitory myeloid receptor), ABI3 (myeloid maturation factor), and LRRC25 (myeloid differentiation). The combination of lysosomal hydrolases with non-classical monocyte markers (FCGR3A, CD300A, ICAM2) defines a non-classical/patrolling monocyte state with active lysosomal/phagocytic capacity. Core coherence supports a tight program. Upregulated significantly in UC/CD inflammation and reduced in remission.
Genes
ABI3, CAMK1, CD300A, CHCHD10, DAPK1, FCGR3A, GNGT2, ICAM2, ITM2B, LRRC25, NAAA, RNASET2, SIDT2, TMEM134
Most correlated modules
- Autophagy Metabolic Stress · correlation 0.91
- Mitochondrial Immune Regulation · correlation 0.86
- Macrophage Differentiation · correlation 0.85
- Non-classical Monocyte State · correlation 0.84
- Tissue Macrophage Identity · correlation 0.76
- Non-classical Monocyte Migration · correlation 0.75
- Non-classical Monocyte · correlation 0.74
- Biosynthetic Metabolic Activation · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.