Macrophage Innate Activation
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Top hub genes MPEG1 (macrophage pore-forming innate effector), SAMHD1 (innate immune dNTPase with antiviral activity), FGL2 (macrophage immunosuppressive fibrinogen-like protein), TLR4 (LPS innate receptor), and PTPRC (CD45, pan-leukocyte phosphatase) collectively define a core macrophage/monocyte innate immune identity program. VPS35 (retromer) supports endosomal recycling relevant to TLR trafficking. Module is significantly upregulated in UC inflammation and reduced in remission, consistent with inflammatory monocyte activation. Neighbor context with M22 (DNA damage/stress) and M29 (tissue remodeling) supports an innate immune activation theme.
Genes
DMXL2, FGL2, HSD17B4, KCTD12, MPEG1, PTPRC, SAMHD1, TLR4, VPS35, ZSWIM6
Most correlated modules
- DNA Damage Response · correlation 0.79
- Inflammatory Monocyte Activation · correlation 0.71
- CCR2+ Monocyte Identity · correlation 0.71
- GIMAP activation · correlation 0.63
- Tissue-Resident Macrophage · correlation 0.62
- M2 Macrophage Polarization · correlation 0.53
- Monocyte Activation State · correlation 0.46
- Monocyte-DC Differentiation · correlation 0.42
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.