Tissue Macrophage Identity
Gene co-expression module in Monocytes
| Category | Tissue homeostasis |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes CSF1R (macrophage differentiation receptor), CMKLR1 (chemerin receptor marking tissue macrophages), SCARB2 (lysosomal scavenger receptor), SNX5 (endosomal sorting), and EPB41L2 (cytoskeletal scaffold) collectively define a tissue-resident macrophage identity and homeostatic program. Decreased in remission and trending up in inflammation suggests these macrophages are enriched in inflamed tissue.
Genes
CMKLR1, CREBL2, CSF1R, DST, EPB41L2, SCARB2, SLC46A1, SNX5
Most correlated modules
- Complement C1q Macrophage · correlation 0.89
- M2 Macrophage Polarization · correlation 0.85
- MHC II Antigen Presentation · correlation 0.83
- Monocyte Lipid Handling · correlation 0.82
- Non-classical Monocyte State · correlation 0.81
- Mitochondrial Immune Regulation · correlation 0.80
- Biosynthetic Metabolic Activation · correlation 0.79
- Efferocytosis Tissue Macrophage · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.