SCUBA

S100A10 — S100 calcium binding protein A10

S100A10 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

S100A10's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsCytotoxic effector
Cytotoxicity
ADAM23, CTSW, EMP3, FKBP2, IFITM2, IGFBP3, KLRG1, LYAR +11 moreView in SCUBA
CD8⁺ T cellsRibosome Biogenesis
RNA processing & translation
BTF3, CCND3, EIF3H, EIF3L, ERP29, FBL, FXYD5, LDHB +8 moreView in SCUBA
EnterocytesHigh-abundance housekeeping
Housekeeping
ARPC3, CD63, CYSTM1, DYNLL1, EIF1, EPCAM, H3-3A, H3-3B +1 moreView in SCUBA
FibroblastsProteolytic Fibroblast State
ECM remodeling
ANXA2, CTSK, EMP3, LGALS3, MPZL1, PCOLCE, ROBO1, S100A16 +3 moreView in SCUBA
Glial cellsS100 Glial Activation
Activation
CDC42EP5, CREB5, CRIP2, EMP3, S100A4, S100A6, TPPP3View in SCUBA
Goblet cellsMucosal Antibacterial Defense
Immune function
ANXA11, B3GNT7, C15orf48, C19orf33, CLIC1, CSTB, CYSTM1, ELOB +8 moreView in SCUBA
Innate lymphoid cellsNK Homing Circulating
Homing & TEM
ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST +37 moreView in SCUBA
MacrophagesInflammatory Monocyte Activation
Inflammatory
ACTN1, ADAM8, AGTRAP, ANXA2, ANXA4, C15orf48, CD44, CD9 +21 moreView in SCUBA
MonocytesInflammatory Monocyte Activation
Inflammatory
ANG, ANXA2, CD99, IGFBP7, MGST1, PLAAT3, RNASE2, ST14View in SCUBA
Mucosal-associated invariant T cellCytotoxic Lymphocyte Program
cytotoxicity
ANXA11, CDKN2D, CYB5A, EMP3, ETHE1, FLT3LG, GLIPR2, LDHB +9 more
Smooth muscle cellsFibroblast Matrisome
ECM remodeling
ADAMDEC1, EMP1, FBLN1, LTBP4, NR2F1, PLTP, PROCR, RGS10 +1 moreView in SCUBA

About the gene

Synonyms42C, ANX2LG, CAL1L, CLP11, P11
Chromosome1: 151982915-151993859
Predicted locationMembrane
Essential geneNo
Protein classPredicted membrane proteins, Transporters

Function

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.