Mitochondrial Immune Regulation
Gene co-expression module in Monocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub gene UCP2 is a mitochondrial uncoupling protein regulating ROS and metabolic reprogramming in monocytes. NDUFAF3 is a Complex I assembly factor. Together with DNASE2 (lysosomal DNase for degrading DNA from phagocytosis), SIGLEC10 (inhibitory immune receptor), DOK2 (negative regulator of signaling), SLC39A1 (zinc importer), and CALHM2 (ATP release/inflammasome regulation), this module reflects mitochondrial metabolic regulation coupled with inhibitory immune signaling in monocytes. Up in CD inflammation, down in remission, consistent with metabolically active inflammatory monocytes.
Genes
CALHM2, CORO1B, DNASE2, DOK2, NDUFAF3, SIGLEC10, SLC39A1, UCP2
Most correlated modules
- Non-classical Monocyte · correlation 0.86
- Non-classical Monocyte State · correlation 0.82
- Tissue Macrophage Identity · correlation 0.80
- Monocyte Lipid Handling · correlation 0.79
- Biosynthetic Metabolic Activation · correlation 0.78
- Autophagy Metabolic Stress · correlation 0.75
- Monocyte Identity · correlation 0.74
- IFN-gamma Monocyte Activation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.