Inflammatory Monocyte Activation
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 14 genes have a known function matching the annotation |
Why this annotation
IFITM2 (interferon-induced transmembrane protein 2, antiviral/inflammatory ISG), TCIRG1 (V-ATPase a3 subunit critical for lysosomal/phagosomal acidification and osteoclast function, expressed in activated monocytes), ALDOA (aldolase A, glycolytic enzyme upregulated in inflammatory macrophages), CLEC2B (C-type lectin receptor on NK cells and monocytes), and TAGLN2 (transgelin-2, actin-binding in activated monocytes) suggest an activated monocyte state with interferon signaling, glycolytic reprogramming, and enhanced lysosomal activity. The significant delta_inflammation_CD signal supports an inflammatory activation program. Several peripheral genes (U2AF1, RNF144B) show only moderate membership, indicating a mixed module. NOTCH2NLB may reflect Notch-driven monocyte activation.
Genes
ALDOA, C11orf98, CLEC2B, CNIH4, CRIP1, GRINA, IFITM2, LEPROTL1, NBPF26, NOTCH2NLB, RNF144B, TAGLN2, TCIRG1, U2AF1
Most correlated modules
- Monocyte Identity · correlation 0.69
- Stress-Adapted Macrophage · correlation 0.62
- IFN-gamma Monocyte Activation · correlation 0.61
- Immediate Early Activation · correlation 0.60
- Inflammatory Autophagy · correlation 0.52
- Non-canonical NF-κB · correlation 0.51
- Type I Interferon Response · correlation 0.48
- Endosomal Sorting · correlation 0.46
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.