Neutrophil Survival FOXO-MK2
Gene co-expression module in Neutrophils
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
FOXO3 is a central regulator of neutrophil apoptosis/lifespan, and MAPKAPK2 (MK2) is the key downstream kinase of p38 MAPK that promotes neutrophil survival by phosphorylating and inhibiting FOXO3. FCAR (CD89/FcαRI) is a neutrophil-specific Fc receptor mediating IgA-triggered effector responses. MAP3K2 provides upstream MAPK input. ARIH1 is an E3 ligase. RAB8B (vesicle trafficking), FGD4 (Rho GEF), IPMK (inositol kinase), and TOP1 are supportive. The FOXO3-MK2 axis defines neutrophil survival/apoptosis regulation.
Genes
ARIH1, FCAR, FGD4, FOXO3, HECA, IPMK, MAP3K2, MAPKAPK2, RAB8B, TOP1
Most correlated modules
- Ubiquitin Regulatory Signaling · correlation 0.97
- PI3K Chemotaxis Signaling · correlation 0.94
- Cytoskeletal Remodeling · correlation 0.90
- TLR2 Innate Signaling · correlation 0.90
- Endosomal Vesicle Trafficking · correlation 0.90
- Ubiquitin-Proteasome Turnover · correlation 0.89
- Endocytic Vesicle Trafficking · correlation 0.89
- Actin Cytoskeletal Remodeling · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.