RAB8B — RAB8B, member RAS oncogene family
RAB8B belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAB8B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NF-kB activation/survival BCR/AP1/NFKb pathway | ARL4C, BCL2A1, CCR7, DDX21, GNG2, ICAM1, IRF2BPL, LMNA +9 more | View in SCUBA |
| CD4⁺ T cells | CCR5 effector migration migration & adhesion | ARHGEF12, BLM, CCR5, EMC6, ERGIC2, IGF2R, KAT2B, PSMD12 +10 more | View in SCUBA |
| Enterocytes | NF-kB epithelial activation Inflammation | BNIP5, CCL20, EHD4, HPS5, IL6ST, NFKBIA, RAP1B, TMPRSS2 +1 more | View in SCUBA |
| Innate lymphoid cells | NF-κB Inflammatory Activation Inflammation | AHI1, CD83, FAM107B, FKBP2, GADD45A, HES4, KDM6B, MRPS36 +7 more | View in SCUBA |
| Macrophages | Microtubule Organization Cytoskeletal | CAMSAP2, DESI2, FAF2, HERPUD2, KCMF1, LSM14A, MAPK6, NRDC +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | Hypoxia-ER Stress Stress | ANKHD1, ARID1A, ARID4B, ATXN7, CEMIP2, CPD, CTDP1, EIF2AK3 +5 more | |
| Neutrophils | Neutrophil Survival FOXO-MK2 Developmental | ARIH1, FCAR, FGD4, FOXO3, HECA, IPMK, MAP3K2, MAPKAPK2 +1 more |
About the gene
| Chromosome | 15: 63189560-63267776 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Protein transport, Transport |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB8B may be involved in polarized vesicular trafficking and neurotransmitter release (Probable). May participate in cell junction dynamics in Sertoli cells (By similarity). May also participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.