Endocytic Vesicle Trafficking
Gene co-expression module in Neutrophils
| Category | Vesicular traficking |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
NUMB is a canonical endocytic adaptor and Notch antagonist that coordinates vesicle budding. PACSIN2 (syndapin II) is an F-BAR domain protein that drives membrane tubulation and endocytosis. TECPR2 is an autophagy receptor involved in autophagic membrane trafficking. SBF2 (MTMR13) is a phosphoinositide phosphatase regulating endosomal sorting. UBE2R2 ubiquitinates cargo for endosomal degradation. CPQ is a membrane carboxypeptidase associated with vesicular compartments. PREX1 (Rac GEF) drives actin remodeling at endocytic sites and also mediates chemokine-directed migration. TBL1X and RBM47 are regulatory but NUMB/PACSIN2/TECPR2/SBF2 form a strong vesicular trafficking core.
Genes
CPQ, NUMB, PACSIN2, PLXDC2, PREX1, RBM47, SBF2, TBL1X, TECPR2, UBE2R2
Most correlated modules
- Granulopoiesis Transcriptional · correlation 0.98
- PI3K Migration Signaling · correlation 0.97
- Endosomal Vesicle Trafficking · correlation 0.97
- TLR2 Innate Signaling · correlation 0.96
- ER Stress Response · correlation 0.94
- Mature Neutrophil Identity · correlation 0.94
- PI3K Chemotaxis Signaling · correlation 0.94
- Ubiquitin-Proteasome Turnover · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.