Ubiquitin Regulatory Signaling
Gene co-expression module in Neutrophils
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes USP9X (deubiquitinase) and FBXW7 (E3 ubiquitin ligase adaptor) anchor a ubiquitin-proteasome regulatory module. SIK3, STK10, and GRB2 contribute kinase/adaptor signaling, while QKI, ARID4B add RNA-binding and chromatin regulation. RAB1A and CYRIB are peripheral. The module represents broad post-translational regulatory housekeeping functions centered on ubiquitin system and kinase signaling, uniformly expressed across neutrophil subsets.
Genes
ARID4B, CYRIB, FBXW7, GRB2, QKI, RAB1A, SIK3, STK10, USP9X
Most correlated modules
- Neutrophil Survival FOXO-MK2 · correlation 0.97
- PI3K Chemotaxis Signaling · correlation 0.96
- Cytoskeletal Remodeling · correlation 0.96
- Endosomal Vesicle Trafficking · correlation 0.94
- Actin Cytoskeletal Remodeling · correlation 0.94
- ELMO-DOCK Chemotaxis · correlation 0.91
- Endocytic Vesicle Trafficking · correlation 0.91
- Granulopoiesis Transcriptional · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.