STK10 — Serine/threonine kinase 10
STK10 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
STK10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory effector Immune regulation | C3AR1, CAST, CLDND1, CMTM3, CREB3L2, EIF4E3, EPB41, FYCO1 +9 more | View in SCUBA |
| Endothelial | Venous Endothelial Identity Endothelial cell development | ACE, ADARB1, CDC42EP1, CLSTN1, EMCN, FLT1, GALNT18, GPRC5B +11 more | View in SCUBA |
| Gamma-delta T cells | TCR Activation Signaling TCR Signaling | ADCY7, ATP2B4, CYFIP2, DIAPH1, GK5, GLG1, ITGAL, NBEAL2 +4 more | |
| Macrophages | Innate Immune Dampening Innate immunity | DCAF6, ELL2, FGD4, FKBP5, IRAK3, MAP2K4, MOB3B, PACSIN2 +10 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Migration migration & adhesion | EFCAB14, IQGAP1, LNPEP, MACF1, MPRIP, OGA, PHF3, PTBP3 +4 more | |
| Natural Killer cells | NK Cell Maturation Differentiation | CAST, GNG2, GZMB, HIPK2, PPP2R5C, PRKCH, SYNE2, ZEB2 | View in SCUBA |
| Neutrophils | Ubiquitin Regulatory Signaling Housekeeping | ARID4B, CYRIB, FBXW7, GRB2, QKI, RAB1A, SIK3, USP9X |
About the gene
| Synonyms | LOK, PRO2729 |
|---|---|
| Chromosome | 5: 172042079-172188224 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Cell cycle |
Function
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.