TLR Lipid Signaling
Gene co-expression module in Neutrophils
| Category | Innate immunity |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes MBOAT7 and DGAT2 are lipid metabolism enzymes (lysophospholipid acyltransferase and diacylglycerol acyltransferase). TLR1, TLR4, and TLR6 are pattern recognition receptors forming heterodimers that sense bacterial lipoproteins. LILRB3 is an inhibitory leukocyte immunoglobulin-like receptor. STEAP4 is a metalloreductase linked to lipid/iron metabolism. IFNAR1 is the type I interferon receptor. PPP1R3B regulates glycogen metabolism. NOTCH1 is a developmental/maturation signal. The co-expression of TLR1/4/6 with lipid-metabolism genes (MBOAT7, DGAT2, STEAP4) and LILRB3 suggests a module reflecting innate immune receptor signaling with coupled lipid remodeling, consistent with TLR-driven membrane lipid reprogramming in neutrophils. Neighbor context: adjacent to M28 (innate/antiviral) and M13 (myeloid receptor signaling), supporting a broad innate immunity theme with a lipid-remodeling flavor.
Genes
DGAT2, IFNAR1, LILRB3, MBOAT7, NOTCH1, PPP1R3B, STEAP4, TLR1, TLR4, TLR6
Most correlated modules
- Mature Neutrophil Identity · correlation 0.90
- Mature Neutrophil Identity · correlation 0.90
- Neutrophil Chemotaxis Receptors · correlation 0.88
- Bacterial Phagocytosis Program · correlation 0.87
- PI3K Migration Signaling · correlation 0.86
- Endocytic Vesicle Trafficking · correlation 0.84
- TLR2 Innate Signaling · correlation 0.83
- TLR5 Bacterial Sensing · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.