DGAT2 — Diacylglycerol O-acyltransferase 2
DGAT2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DGAT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Inflammatory Metabolic Reprogramming Inflammatory | ACTN1, ADAM8, EAF1, GPAT3, MCTP2, PTPN7, SLC25A37, SLC2A3 | View in SCUBA |
| Neutrophils | TLR Lipid Signaling Innate immunity | IFNAR1, LILRB3, MBOAT7, NOTCH1, PPP1R3B, STEAP4, TLR1, TLR4 +1 more |
About the gene
| Chromosome | 11: 75759512-75801535 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Glycerol metabolism, Lipid biosynthesis, Lipid metabolism |
Function
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Also functions as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1- monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.