SBF2 — SET binding factor 2
SBF2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SBF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Focal adhesion actin Migration & adhesion | BAZ2B, CARMIL1, COP1, FRYL, KIF13A, LPP, MYO6, PALLD +4 more | View in SCUBA |
| Gamma-delta T cells | gd T Cell Identity T cell maturation | AKAP17A, CNNM3, GALNT11, KCNA3, MECP2, PIEZO1, PLXNC1, RASGEF1A +6 more | |
| Lymphatic endothelial | Cilia Centrosome Program Cytoskeletal | ARB2A, BBS9, BCAS3, CDKAL1, CEP112, EPB41L4A, FCHSD2, FTO +7 more | View in SCUBA |
| Macrophages | Golgi Vesicle Trafficking Vesicular traficking | ARMH3, ATG7, CCDC91, CDK17, CLASP1, COG5, COMMD10, COP1 +24 more | View in SCUBA |
| Neutrophils | Endocytic Vesicle Trafficking Vesicular traficking | CPQ, NUMB, PACSIN2, PLXDC2, PREX1, RBM47, TBL1X, TECPR2 +1 more |
About the gene
| Synonyms | CMT4B2, DENND7B, KIAA1766, MTMR13 |
|---|---|
| Chromosome | 11: 9776776-10304877 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
| Biological process | Autophagy |
Function
Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Acts as an adapter for the phosphatase MTMR2 (By similarity). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.