Golgi Vesicular Trafficking
Gene co-expression module in Pericytes
| Category | Vesicular traficking |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Top hub TGOLN2 (trans-Golgi network protein 2) is a canonical Golgi marker. PTTG1IP (pituitary tumor-transforming gene interacting protein) localizes to the Golgi and ER. SERINC3 and TMEM109 are ER/membrane proteins involved in lipid incorporation and ER homeostasis. APP (amyloid precursor protein) traffics through the secretory pathway via Golgi. CLIC4 participates in vesicular trafficking and membrane dynamics. PAK2 regulates vesicle budding. EMP2 is a tetraspan membrane protein involved in membrane trafficking. CTNNA1 (alpha-catenin) is somewhat divergent but can associate with vesicular/membrane complexes. GNAS (G-protein alpha s) is a weak member and may reflect upstream regulation of Golgi dynamics. The module strongly represents Golgi/vesicular trafficking.
Genes
APP, CLIC4, CTNNA1, EMP2, GNAS, PAK2, PTTG1IP, SERINC3, TGOLN2, TMEM109
Most correlated modules
- ER-Actin Cytoskeletal · correlation 0.97
- G1 Cell Cycle Entry · correlation 0.94
- RAS Cytoskeletal Signaling · correlation 0.94
- G-protein Signaling Scaffold · correlation 0.94
- BMP Receptor Signaling · correlation 0.94
- Actin-ERM Migration · correlation 0.93
- mRNA Stability Regulation · correlation 0.93
- RAS-Chromatin Signaling · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.