Type I Interferon
Gene co-expression module in Pericytes
| Category | Inflammatory |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes IFI6, IFI44L, IFI16, MX1 are canonical type I interferon-stimulated genes. SP100 is an interferon-induced PML nuclear body component. XAF1 is an ISG that promotes apoptosis. TNFRSF1A fits the inflammatory/antiviral context. Module is significantly upregulated in CD inflammation. RCN1 and PPIC are weaker peripheral members. Neighbor to M82 which contains immunoproteasome genes, consistent with shared IFN-driven upstream regulation.
Genes
IFI16, IFI44L, IFI6, MX1, PPIC, RCN1, SP100, TNFRSF1A, XAF1
Most correlated modules
- RNA Splicing Processing · correlation 0.92
- RAS Cytoskeletal Signaling · correlation 0.91
- G-protein Signaling Scaffold · correlation 0.91
- Golgi Vesicular Trafficking · correlation 0.91
- mRNA Stability Regulation · correlation 0.90
- ER-Actin Cytoskeletal · correlation 0.89
- Immunoproteasome Induction · correlation 0.88
- Mitochondrial OxPhos · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.