RAS Cytoskeletal Signaling
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes KRAS (RAS GTPase), ARPC5L (Arp2/3 actin branching complex), PTPN12 (cytoskeletal tyrosine phosphatase), PEA15 (RAS/ERK scaffold, anti-apoptotic), LRRFIP1 (actin binding/innate immune), and KLF3 (transcription factor downstream of RAS) collectively point to a RAS-driven cytoskeletal signaling program. Core coherence and uniform expression across pericyte subsets support a constitutive pericyte signaling state. UBE2J1 (ER-associated ubiquitin conjugating enzyme) and CNDP2 (cytosolic dipeptidase) are peripheral. The dominant theme is RAS/actin cytoskeletal signaling.
Genes
ARPC5L, CNDP2, FAM177A1, KLF3, KRAS, LRRFIP1, PEA15, PTPN12, UBE2J1
Most correlated modules
- Actin-ERM Migration · correlation 0.97
- BMP Receptor Signaling · correlation 0.95
- TGF-beta Negative Feedback · correlation 0.95
- G1 Cell Cycle Entry · correlation 0.95
- Golgi Vesicular Trafficking · correlation 0.94
- Vascular Junction Adhesion · correlation 0.94
- G-protein Signaling Scaffold · correlation 0.94
- RNA Splicing Processing · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.