RAS-Chromatin Signaling
Gene co-expression module in Pericytes
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include SOS1 (RAS guanine nucleotide exchange factor, RTK/MAPK signaling), SMARCA2 (SWI/SNF chromatin remodeling ATPase, transcriptional regulation), SKAP2 (signaling adapter for integrin/immune signaling), CD2AP (actin-organizing scaffold expressed in pericytes/podocytes), WNK1 (with-no-lysine kinase regulating ion transport and osmotic stress), CNOT6L (CCR4-NOT deadenylase, mRNA stability), and EFCAB14 (EF-hand calcium binding). This module is notably NOT significantly downregulated in inflammation (unlike all neighbors), suggesting it represents a constitutive signal transduction and chromatin regulation program rather than a disease-responsive vascular identity program. The combination of RAS signaling (SOS1), chromatin remodeling (SMARCA2), and mRNA decay (CNOT6L) suggests general transcriptional/post-transcriptional regulation.
Genes
CD2AP, CNOT6L, EFCAB14, SKAP2, SMARCA2, SOS1, TMTC1, WNK1
Most correlated modules
- G1 Cell Cycle Entry · correlation 0.95
- Notch Vascular Development · correlation 0.95
- Vascular Barrier Integrity · correlation 0.95
- Vascular Identity TFs · correlation 0.94
- Arterial Identity TFs · correlation 0.94
- Golgi Vesicular Trafficking · correlation 0.93
- Vascular Tone Homeostasis · correlation 0.93
- MHC-II Antigen Presentation · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.