Basement Membrane Assembly
Gene co-expression module in Pericytes
| Category | ECM production |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include SEC31A (COPII vesicle coat protein for secretory pathway), LAMC1, NID1, LAMA4 (basement membrane laminins and nidogen), F2R (PAR1 thrombin receptor), LIMS1 and ITGB1 (integrin adhesion complex), JAK1 (cytokine receptor signaling), and FARP1 (Rho GEF). The laminin/nidogen combination points to basement membrane assembly; ITGB1/LIMS1 mediate integrin-ECM adhesion. SEC31A reflects active secretory trafficking of BM components. Inflammation-responsive. Neighbor to M53 (BM collagens) and M63 (fibrillar collagens), supporting a BM assembly/adhesion program.
Genes
F2R, FARP1, ITGB1, JAK1, LAMA4, LAMC1, LIMS1, NID1, PELO, SEC31A
Most correlated modules
- BM Collagen Production · correlation 0.93
- Fibrotic ECM Remodeling · correlation 0.90
- ER Protein Folding · correlation 0.86
- Fibrillar Collagen Production · correlation 0.85
- Pericyte Inflammatory Activation · correlation 0.84
- Focal Adhesion Cytoskeleton · correlation 0.84
- TGF-β Cytoskeletal Remodeling · correlation 0.83
- Complement Regulatory Pericyte · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.