Basement Membrane Remodeling
Gene co-expression module in Pericytes
| Category | ECM remodeling |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
LAMB3 (laminin β3), TIMP1 (TIMP metalloproteinase inhibitor-1), EFEMP2 (fibulin-4/FBLN4, elastic fiber ECM), and RCN3 (ER calcium-binding, collagen folding) form a basement membrane/ECM remodeling core. DKK3 is a pericyte marker and Wnt modulator. CYBA encodes p22-phox (NADPH oxidase subunit, ROS). ISG20 is interferon-stimulated. G0S2 regulates cell quiescence. TSPAN15 regulates ADAM10 (ECM shedding). ADA modulates adenosine. The dominant signal is ECM remodeling/basement membrane production with strong inflammation upregulation (delta ~1.4). TIMP1 specifically inhibits MMPs to preserve ECM during inflammation.
Genes
ADA, C4orf48, CYBA, DKK3, EFEMP2, G0S2, ISG20, LAMB3, RCN3, TIMP1, TSPAN15
Most correlated modules
- Fibrotic ECM Remodeling · correlation 0.92
- ER Protein Folding · correlation 0.91
- Inflammatory Pericyte Activation · correlation 0.90
- Pericyte Inflammatory Activation · correlation 0.85
- Fibrillar Collagen Production · correlation 0.84
- Complement Regulatory Pericyte · correlation 0.84
- BM Collagen Production · correlation 0.83
- Basement Membrane Assembly · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.