Complement Regulatory Pericyte
Gene co-expression module in Pericytes
| Category | Inflammatory |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
IGFBP7 and MGP are well-established pericyte identity markers. SERPING1 (C1-inhibitor) and CFH are complement regulatory proteins upregulated in inflamed stroma. CD63 marks lysosomal/exosomal compartments. SELENOM is an ER selenoprotein involved in redox homeostasis. LGALS1 is an immunomodulatory lectin. ACTN1 links to cytoskeletal anchoring. The module is upregulated in UC/CD inflammation and partially reversed by treatment, suggesting an inflammatory complement-regulatory pericyte state. Neighbor context: shares cytoskeletal (ACTN1) overlap with M29 and ECM (MGP) overlap with M51, consistent with topological proximity.
Genes
ACTN1, CD63, CFH, IGFBP7, LGALS1, MGP, SELENOM, SERPING1
Most correlated modules
- Focal Adhesion Cytoskeleton · correlation 0.92
- Pericyte ECM Production · correlation 0.88
- Inflammatory Pericyte Activation · correlation 0.87
- Basement Membrane Remodeling · correlation 0.84
- Fibrillar Collagen Production · correlation 0.83
- Basement Membrane Assembly · correlation 0.83
- Pericyte Inflammatory Activation · correlation 0.82
- Inflammatory ECM Remodeling · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.