ADAMTS4 — ADAM metallopeptidase with thrombospondin type 1 motif 4
ADAMTS4 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADAMTS4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Wnt Angiogenic Remodeling ECM remodeling | ADGRL2, BAZ1A, FKBP11, IL4R, LDLRAD3, LEF1, MTHFD2, NEURL1B +5 more | View in SCUBA |
| Fibroblasts | Inflammatory TF Response Inflammatory | CEBPD, CMIP, FOSL2, KLF9, MAT2A, NR4A1, NR4A2, NR4A3 +2 more | View in SCUBA |
| Pericytes | Cytokine Inflammatory Response Inflammatory | C11orf96, CEBPB, CEBPD, GEM, ID4, KCNE4, PHLDA1, RGS16 +4 more | View in SCUBA |
| Smooth muscle cells | NR4A-ADAMTS Activation Stress | ADAMTS1, ADAMTS9, AVPR1A, DUSP8, HIPK2, KLF9, MYC, NR4A1 +5 more | View in SCUBA |
About the gene
| Synonyms | ADAMTS-2, ADMP-1, KIAA0688 |
|---|---|
| Chromosome | 1: 161184302-161199054 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted secreted proteins, Transporters |
| Molecular function | Hydrolase, Metalloprotease, Protease |
Function
Cleaves aggrecan, a cartilage proteoglycan, at the '392- Glu-|-Ala-393' site and may be involved in its turnover. Also cleaves COMP. May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.