Pericyte Inflammatory Activation
Gene co-expression module in Pericytes
| Category | Inflammatory |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include PDGFA (pericyte-derived growth factor), KCNJ8 (Kir6.1, canonical pericyte marker), RUNX1 and BATF3 (AP-1/RUNX transcription factors activated in inflammation), RHOQ/RHOBTB3 (Rho GTPase signaling), VASN (TGF-β antagonist), and CRISPLD2 (anti-inflammatory secreted protein). The module shows the strongest inflammation signal in the batch (delta_UC=0.882, delta_CD=0.918) and reverses with treatment/remission. RUNX1+BATF3 suggest a transcriptional inflammatory activation program operating in pericytes. PDGFA and KCNJ8 confirm pericyte identity. This represents an inflammatory transcriptional activation state in pericytes.
Genes
BATF3, CRISPLD2, FILIP1L, KCNJ8, MARCKS, PAG1, PDGFA, RHOBTB3, RHOQ, RUNX1, SGIP1, VASN
Most correlated modules
- Fibrillar Collagen Production · correlation 0.90
- Fibrotic ECM Remodeling · correlation 0.89
- BM Collagen Production · correlation 0.87
- Pericyte Identity Signaling · correlation 0.86
- Basement Membrane Remodeling · correlation 0.85
- Basement Membrane Assembly · correlation 0.84
- Pericyte ECM Production · correlation 0.84
- Complement Regulatory Pericyte · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.